Evaluación In Silico De La Afinidad De 12 Moléculas Sobre Proteínas Involucradas En La Formación De Biopelicula De Streptococcus Mutans
Share
Date
2022-06-21
Director(s)
Publisher
Universidad Antonio Nariño
Campus
Faculty
Program
Degree obtained
Document type
COAR type
http://purl.org/coar/resource_type/c_7a1f
Citation
Bibliographic Managers
Document Viewer
Select a file to preview:
item.page.resume
Abstract
Of the infectious diseases affecting humans, dental caries is probably the most prevalent. Dental
caries is described as a dynamic process of demineralization and remineralization, a product of
bacterial metabolism on the tooth surface, which over time can produce a net loss of minerals and
possibly, but not always, result in the presence of a cavity. Oral bacteria belong to a complex
community of numerous species that participate in the formation of bacterial plaque (biofilm or
biofilm) with all its functions, interactions and properties. The current concept contemplates that
several microorganisms are included in the pathogenesis of dental caries, with Streptococcus
mutans being the most important agent associated with it.
Streptococcus mutans has different proteins involved in biofilm formation. Bioinformatics
strategies for the search of drugs for the treatment of different diseases can be used in dentistry,
so with this work it was possible to evaluate In silico the affinity of twelve molecules on proteins
involved in the biofilm formation of Streptococcus mutans. Twelve molecules previously
reported by (Rivera-Quiroga et al., 2021) were selected and remote docking with six proteins
GBP-C, CE4 esterase, GTF-C, sortase A and two Ag I/II domains were performed to identify the
affinity of these molecules on these proteins
Keywords
item.page.subject.keyword
item.page.coverage.spatial
Aremenia, Quindio , Colombia