Sistema y método para estimar la dosis de radiación ultravioleta durante la esterilización del nitrógeno líquido

dc.contributor.advisorMoreno López, Deywisspa
dc.contributor.advisorRodriguez Suarez, Cesar Augustospa
dc.contributor.advisorHernández, Andrés Ignaciospa
dc.contributor.authorDelgado Gonzalez, Maritza Juliettespa
dc.creator.cedula53068081spa
dc.creator.cedula79728622spa
dc.creator.cedula10025092spa
dc.creator.cedula80417160spa
dc.creator.cvlachttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001343755spa
dc.creator.orcidhttps://orcid.org/0000-0002-2646-620Xspa
dc.date.accessioned2021-02-26T14:01:41Z
dc.date.available2021-02-26T14:01:41Z
dc.date.issued2020-11-24spa
dc.descriptionExternaes_ES
dc.description.abstractAt the moment, there is no dosimeter that provides a real-time measurement of ultraviolet radiation dose at cryogenic temperatures during the sterilization of liquid nitrogen, because the technical parameters are defined at room temperature, and many of these change dramatically at temperature of -195 °C. In this work, a prototype of a cryogenic dosimeter based on Silicon photomultipliers (SiPM) is designed, useful for characterizing the dose of ultraviolet radiation measured in real time for quality control of cryogenic applications in medicine, biology, biotechnology and industry. In this study, a simulation with optical photons (253 nm) was performed in liquid and gaseous nitrogen, using Geant4 simulation toolkit. The results present a zone of minimal UV radiation inside a container of liquid nitrogen, and a method for estimating the radiation dose with one or more cryogenic SiPMs, located inside the container, especially in the minimum radiation zone in order to certify the absence of microorganisms in the liquid nitrogen.eng
dc.description.abstractEn la actualidad, no es posible encontrar un dosímetro que proporcione una medida de la dosis de radiación ultravioleta en tiempo real a temperatura criogénica durante la esterilización del nitrógeno líquido, ya que sus parámetros técnicos se definen a temperatura ambiente, y muchos de estos cambian drásticamente a una temperatura de -195°C. En este trabajo se diseña un prototipo de un dosímetro criogénico basado en fotomultiplicadores de Silicio (SiPM), útil para la caracterización de la dosis de radiación ultravioleta medida en tiempo real para controles de calidad en aplicaciones criogénicas en medicina, biología, biotecnología e industria. En este estudio se realizó una simulación con fotones ópticos (253 nm) en nitrógeno líquido y gaseoso, utilizando el kit de herramientas de simulación Geant4. Los resultados presentan una zona de mínima radiación UV dentro de un contenedor de nitrógeno líquido y un método para la estimación de la dosis de radiación con uno o más SiPM´s criogénicos ubicados dentro del contenedor, especialmente, en la zona mínima de radiación con el fin de certificar la ausencia de microorganismos dentro del nitrógeno líquido.spa
dc.description.degreelevelDoctoradospa
dc.description.degreenameDoctor(a) en Ciencia Aplicadaspa
dc.description.funderConvocatoria Doctorados Nacionales, 757, 2016es_ES
dc.description.notesPresencialspa
dc.description.sponsorshipOtrospa
dc.identifier.bibliographicCitationAbi, B. e. (2020). Introduction to DUNE. Journal of Instrumentation, Volume 15.spa
dc.identifier.bibliographicCitationAbi, B. e. (2020). The DUNE far detector single phase technology. Journal of Instrumentation, Volume 15.spa
dc.identifier.bibliographicCitationAcciari, R. e. (2011). Test and Comparison of Photomultiplier Tubes at Liquid Argon Temperature. Technology and Instrumentation for Particle Physics., 1087-1094.spa
dc.identifier.bibliographicCitationAcciari, R. e. (2017). Design and Construction of the MicroBooNE Detector. Journal of instrumentation.spa
dc.identifier.bibliographicCitationAcerbia, F., & Gundackerbc, S. (2019). Understanding and simulating SiPMs. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 16-35.spa
dc.identifier.bibliographicCitationAgostinelliae, S., & Allisonas, J. (2003). Geant4 a simulation toolkit. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 250-303.spa
dc.identifier.bibliographicCitationÁlvarez, V. e. (2012). NEXT-100 Technical Design Report (TDR). Executive summary. Journal of instrumentation, Vol 7.spa
dc.identifier.bibliographicCitationBakkali, J., Doudouh, A., & Mansouri, H. (2018). Assessment of Monte Carlo Geant4 capabilities in prediction of photon beam dose distribution in a heterogeneous medium. Physics in medicine, 1-5.spa
dc.identifier.bibliographicCitationBerra, A. e. (2015). A SiPM based real time dosimeter for radiotherapic beams. Nuclear Instruments and Methods in Physics Research A, 72-80.spa
dc.identifier.bibliographicCitationBielanski, A. e. (2003). Microbial contamination of embryos and semen during long term banking in liquid nitrogen. Cryobiology, 146-152.spa
dc.identifier.bibliographicCitationBirmpa, A., Sfika, V., & Vantarakis, A. (2013). Ultraviolet light and Ultrasound as non-thermal treatments for the inactivation of microorganisms in fresh ready-to-eat foods. International Journal of Food Microbiology, 96-102.spa
dc.identifier.bibliographicCitationBoullard, A., & Giacomoni, P. U. (1988). Effect of UV irradiation at defined wavelengths on the tertiary structure of double-stranded covalently closed circular DNA. Journal of Photochemistry and Photobiology B: Biology, 491-501.spa
dc.identifier.bibliographicCitationCervi, T. e. (2017). Study oSiPM custom arrays for scintillation light detection in a Liquid Argon Time Projection Chamber. Journal of Instrumentation, Volume 12.spa
dc.identifier.bibliographicCitationChang, J. C., & et al. (1985). UV Inactivation of Pathogenic and Indicator Microorganisms. Applied and environmental microbiology, 1361-1365.spa
dc.identifier.bibliographicCitationElder, K., Bergh, M. V., & Woodward, B. (2015). Troubleshooting and problem-Solving in the IVF Laboratory. United Kingdom: Cambridge University Press.spa
dc.identifier.bibliographicCitationEPA, A. U. (2003). Ultra Violet Disinfection Special Manual. U.S.Environmental Protection Agency. Washington: EPA 815-D-03-007.spa
dc.identifier.bibliographicCitationFalcone, A. e. (2020). Cryogenic SiPM arrays for the DUNE photon detection system. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1646-1648.spa
dc.identifier.bibliographicCitationGerba, C. P., Gramos, D. M., & Nwachuku, N. (2002). Comparative Inactivation of Enteroviruses and Adenovirus 2 by UV Light. Applied and Environmental Microbiology, 5167-5169.spa
dc.identifier.bibliographicCitationGrace, E., & et al. (2017). Index of refraction, Rayleigh scattering length, and Sellmeier coefficients in solid and liquid argon and xenon. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 204-208.spa
dc.identifier.bibliographicCitationGriesmann, U., & Burnett, J. (1999). Refractivity of nitrogen gas in the vacuum ultraviolet. Optics Letters, 1699-1701.spa
dc.identifier.bibliographicCitationGutiérrez, A., López, M. A., Palou, E., & Ramirez, C. N. (2015). Métodos para la determinación de la dosis de radiación ultravioleta de onda corta (UVC) en alimentos. Temas selectos de Ingeniería de alimentos, 34-40.spa
dc.identifier.bibliographicCitationHurst, C. J. (2017). Modeling the Transmission and Prevention of infectious Desease. USA: Springer.spa
dc.identifier.bibliographicCitationINVIMA. (2009). Manual de buenas practicas de Manufactura de los Gases Medicinales. Bogotá: Ministerio de Salud y Protección Social de Colombia.spa
dc.identifier.bibliographicCitationIsachenko, V. e. (2010). Human ovarian tissue cryopreservation: quality of follicles as a criterion of effectiveness. Reproductive BioMedicine, 441-442.spa
dc.identifier.bibliographicCitationISO14161. (2000). esterilización de productos sanitarios : indicadores biológicos : orientación para la selección, la utilización y la interpretación de los resultados. AENOR.spa
dc.identifier.bibliographicCitationJoaquim, D. C., Borges, E. D., Viana, L. G., Navarro, P. A., & Vireque, A. A. (2017). Risk of Contamination of Gametes and Embryos during Cryopreservation and Measures to Prevent Cross-Contamination. BioMed Research International, 11.spa
dc.identifier.bibliographicCitationKryczynski, P. e. (2016). Scintillation light detection system in LArIAT. Journal of Instrumentation, Volume 11.spa
dc.identifier.bibliographicCitationLeo, W. R. (1987). Techniques for Nuclear and Particle Experiments. Berlín: Springer.spa
dc.identifier.bibliographicCitationMachado, A., & Segreto, E. (2016). ARAPUCA a new device for liquid argon scintillation light detection. Journal of Instrumentation,, Volume 11.spa
dc.identifier.bibliographicCitationMorris, G. (2005). The origin, ultrastructure, and microbiology of the sediment accumulating in liquid nitrogen storage vessels. Cryobiology, 231-238.spa
dc.identifier.bibliographicCitationParmegiani Lodovico, C. G. (2009). Ultra-violet sterilization of liquid nitrogen prior to vitrification. Human Reproduction, 2969.spa
dc.identifier.bibliographicCitationParmegiani, L., & et al. (2009). Sterilization of liquid nitrogen with ultraviolet irradiation for safe vitrification of human oocytes or embryos. Techniques and instrumentation, 1525-1528.spa
dc.identifier.bibliographicCitationParmegiani, L., Cognigni, G. E., & Filicori, M. (2011). Efficacy of ultraviolet sterilization of liquid nitrogen. Reproductive Medicine, 22.spa
dc.identifier.bibliographicCitationPessoa, G., Batistella, M., Mondino, C., & Costa da Rosa, D. (2014). Decontamination of naturally contaminated liquid nitrogen storage tanks. Revista Brasileira de Zootecnia., 5.spa
dc.identifier.bibliographicCitationRivero, G. J. (2012). CAPÍTULO I. GENERALIDADES DE LA CRIOPRESERVACIÓN. En G. J. Rivero, Modelado matemático e implementación práctica de sistema de vitrificación ultra-rápida mediante radiación láser (págs. 8-23). Sevilla: Universidad de Sevilla.spa
dc.identifier.bibliographicCitationSchalk, S., Adam, V., Arnold, E., & Brieden, K. (2005). UV-Lamps for Disinfection and Advanced Oxidation - Lamp Types,Technologies and Applications. IUVA News, 32-37.spa
dc.identifier.bibliographicCitationScotto, M. (2003). Molecular Motion and Raman Band Shapes in Liquid Nitrogen and Oxygen. The Journal of Chemical Physics, 5362.spa
dc.identifier.bibliographicCitationWhittington, D. (2015). Photon Detection System Designs for the Deep Underground Neutrino Experiment. arXiv.spa
dc.identifier.bibliographicCitationWischnewski , B. (Junio de 2007). peacesoftware. Berlín, Wagner-Str. 49, Alemania.spa
dc.identifier.bibliographicCitationYonezawa, F., & Ninomiya, T. (1982). Topological Disorder in Condensed Matter. Shimoda: Springer.spa
dc.identifier.instnameinstname:Universidad Antonio Nariñospa
dc.identifier.reponamereponame:Repositorio Institucional UANspa
dc.identifier.repourlrepourl:https://repositorio.uan.edu.co/spa
dc.identifier.urihttp://repositorio.uan.edu.co/handle/123456789/1971
dc.language.isospaspa
dc.publisherUniversidad Antonio Nariñospa
dc.publisher.campusBogotá - Circunvalarspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.programDoctorado en Ciencia Aplicadaspa
dc.rightsAcceso restringido
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_16ecspa
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subjectRadiación Ultravioleta, Nitrogeno Líquido, Esterilización, Silicon Photomultiplier, Geant4es_ES
dc.subject.keywordUltraviolet Radiation, Liquid Nitrogen, Sterilization, Silicon Photomultiplier, Geant4es_ES
dc.titleSistema y método para estimar la dosis de radiación ultravioleta durante la esterilización del nitrógeno líquidoes_ES
dc.typeTesis y disertaciones (Maestría y/o Doctorado)spa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
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