Estimación de la relación entre las proteínas plasmáticas de la yegua y los niveles de IgG séricos en otros neonatos de 24 horas de edad
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2023-10-30
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Universidad Antonio Nariño
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Abstract
The level of serum immunoglobulin G in horses is of utmost importance since it gives
origin of defense mechanisms mediated by antibodies which bind to antigens
specific as those found on the surface of bacteria, in horses the level
of Immunoglobulin G is 1000 to 1500 mg/dl, being the immunoglobulin that reaches the highest
concentration in the blood. In the case of the mare, the placenta is of the epitheliochorial type, this
anatomical condition prevents the correct transfer of immunoglobulins to the fetus during
gestation and also serves as a barrier to environmental pathogens. (Carabetta, Fernandez,2016).
Foals must ingest an appropriate amount of colostrum in order to acquire a
efficient passive immunity since, due to its type of placenta, foals can be born
agamaglobulinemic (Jeffcott, 1974).
Passive transfer failure (FTP) occurs when there is no good absorption of
colostrum throughout the first 24 hours of life or the colostrum does not have the quality or production
suitable in the case of first-time or very old mares, this gives rise to a
deficiency in the transfer of maternal antibodies especially immunoglobulin G
(IgG), which increases the predisposition to infectious diseases and death of foals in
his first days of life. (Palomino J, 2021)
The decrease in the absorption of immunoglobulins by the foal as
As time progresses, it is due to the response of the specialized enterocytes desquamation with
pinocytosis capacity and its replacement by more mature cells that are capable of
absorb immunoglobulins in the intestine for a limited time, this ranges from the
8
birth until the first 18 to 24 hours of life. (Barrington and Johnson, 2010; Corley and
Jokisalo, 2015).
Equine neonatal septicemia is the systemic inflammatory response to infection,
There is a wide variety of events that can facilitate sepsis in the foal and these are
described taking into account maternal and postnatal factors. Maternal factors include
difficulty in childbirth, early separation of the 13 placental membranes, placentitis and others
forms of illness such as those associated with signs of colic, pneumonia, among others. The
Most maternal events that cause septicemia in the foal are related to
Acute or chronic ascending placentitis. Postnatal causes are related to possible
infection routes. However, there is one major exception, the failure of passive transfer of
immunoglobulins (mainly IgG), which is defined as the inadequate transfer of
colostral antibodies from the mare to the foal, or as an inadequate absorption of them by
part of the neonate. It is believed to be the major cause of predisposition to infections and death of
foals in their first days of life (Ospina, 2014). being the major cause of mortality and
morbidity in horses in their first seven days of life, this causes great losses
economics to the equine industry. The disease and its consequences are reflected as stages
progressive processes of the same process, in which the systemic response to the infection can generate
a generalized inflammatory reaction in organs distant from the initial injury and induce
multi-organ dysfunction or failure. (Arroyave, D.J, 2017).
Keywords
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Colombia( Popayán, Cauca)