Potencial antitumoral de propóleos colombianos: caracterización química y mecanismos involucrados en la citotoxicidad in vitro contra osteosarcoma canino

Simple item page
dc.contributor.advisorTorres García, Orlandospa
dc.contributor.advisorSforcin, Jose Mauriciospa
dc.contributor.advisorGutiérrez, Rafael Maríaspa
dc.contributor.authorPardo Mora, Dolly Patriciaspa
dc.creator.cedula13001615407spa
dc.date.accessioned2023-05-23T21:19:57Z
dc.date.available2023-05-23T21:19:57Z
dc.date.issued2018-02-18spa
dc.description.abstractPropolis is produced by honeybees from the resins and balsams of plants and characterized by its complex chemical composition. Bees use propolis to protect the hive, to seal holes and to avoid infectious diseases that may affect bee health. Humans have used propolis for medicinal purposes since ancient times, and its effectiveness as an antimicrobial, immunomodulatory, antiparasitic, and antitumor agent has been demonstrated recently.eng
dc.description.abstractEl propóleo es un material producido por las abejas a partir de resinas y bálsamos de plantas, caracterizado por su compleja composición química. Las abejas lo utilizan como medio de protección, sellando espacios y adicionalmente para evitar procesos infecciosos que puedan afectar la salud de la colmena. El humano ha usado el propóleo desde tiempos ancestrales con fines medicinales y en la época moderna ha sido posible demostrar su efecto como antimicrobiano, inmunomodulador, antiparasitario y antitumoral, entre otros.spa
dc.description.degreelevelDoctoradospa
dc.description.degreenameDoctor(a) en Ciencia Aplicadaspa
dc.description.degreetypeMonografíaspa
dc.description.notesPresencialspa
dc.identifier.bibliographicCitationAhn, M. R., Kunimasa, K., Ohta, T., Kumazawa, S., Kamihira, M., Kaji, K., . . . Nakayama, T. (2007). Suppression of tumor-induced angiogenesis by Brazilian propolis: Major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation. Cancer Letters, 252(2), 235-243. doi:10.1016/j.canlet.2006.12.039spa
dc.identifier.bibliographicCitationAl-Khan A., Gunn H.J., Day M.J., Tayebi M., Ryan S.D., Kuntz C.A., Saad E.S., Richardson S.J., Danks J.A. 2017. Immunohistochemical Validation of Spontaneously Arising Canine Osteosarcoma as a Model for Human Osteosarcoma. Journal of Comparative Pathology. Volume 157, Issue 4: 256-265spa
dc.identifier.bibliographicCitationAlday, E., Valencia, D., Carreno, A. L., Picerno, P., Piccinelli, A. L., Rastrelli, L., . . . Velazquez, C. (2015). Apoptotic induction by pinobanksin and some of its ester derivatives from Sonoran propolis in a B-cell lymphoma cell line. Chemico-Biological Interactions, 242, 35-44. doi:10.1016/j.cbi.2015.09.013spa
dc.identifier.bibliographicCitationBankova, Castro, D., & Marcucci. (2000). Propolis: Recent advances in chemistry and plant origin. Apidologie, 31(1), 3-15.spa
dc.identifier.bibliographicCitationBankova, V. (2005). Chemical diversity of propolis and the problem of standardization. Journal of Ethnopharmacology, 100(1–2), 114-117. doi:http://dx.doi.org/10.1016/j.jep.2005.05.004spa
dc.identifier.bibliographicCitationBankova, V., Popova, M., & Trusheva, B. (2016). NEW EMERGING FIELDS OF APPLICATION OF PROPOLIS. Macedonian Journal of Chemistry and Chemical Engineering, 35(1), 1-11. doi:10.20450/mjcce.2016.864spa
dc.identifier.bibliographicCitationBartolomeu, A. R., Frión-Herrera, Y., da Silva, L. M., Romagnoli, G. G., de Oliveira, D. E., & Sforcin, J. M. (2016). Combinatorial effects of geopropolis produced by Melipona fasciculata Smith with anticancer drugs against human laryngeal epidermoid carcinoma (HEp-2) cells. Biomedicine & Pharmacotherapy, 81, 48-55. doi:http://dx.doi.org/10.1016/j.biopha.2016.03.049spa
dc.identifier.bibliographicCitationBernardino, P.N., Bersano, P.R.O., Lima Neto, J.F., Sforcin, J.M. Positive effects of antitumor drugs in combination with propolis on canine osteosarcoma cells (spOS- 2) and mesenchymal stem cells. Biomedicine & Pharmacotherapy, in press.spa
dc.identifier.bibliographicCitationBertram, J. S. (2000). The molecular biology of cancer. Molecular Aspects of Medicine, 21(6), 167-223. doi:http://dx.doi.org/10.1016/S0098-2997(00)00007-8spa
dc.identifier.bibliographicCitationBittencourt, M. L. F., Ribeiro, P. R., Franco, R. L. P., Hilhorst, H. W. M., de Castro, R. D., & Fernandez, L. G. (2015). Metabolite profiling, antioxidant and antibacterial activities of Brazilian propolis: Use of correlation and multivariate analyses to identify potential bioactive compounds. Food Research International, 76, 449-457. doi:10.1016/j.foodres.2015.07.008spa
dc.identifier.instnameinstname:Universidad Antonio Nariñospa
dc.identifier.reponamereponame:Repositorio Institucional UANspa
dc.identifier.repourlrepourl:https://repositorio.uan.edu.co/spa
dc.identifier.urihttp://repositorio.uan.edu.co/handle/123456789/8027
dc.language.isospaspa
dc.publisherUniversidad Antonio Nariñospa
dc.publisher.campusBogotá - Circunvalarspa
dc.publisher.facultyDoctorado en Ciencia Aplicadaspa
dc.publisher.programDoctorado en Ciencia Aplicadaspa
dc.rightsAcceso abierto
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subjectPropóleoes_ES
dc.subjectOsteosarcomaes_ES
dc.subjectApoptosises_ES
dc.subjectExpresión génica.es_ES
dc.subject.ddc14.18 P226pes_ES
dc.subject.keywordPropolises_ES
dc.subject.keywordOsteosarcomaes_ES
dc.subject.keywordApoptosises_ES
dc.subject.keywordGene Expressiones_ES
dc.titlePotencial antitumoral de propóleos colombianos: caracterización química y mecanismos involucrados en la citotoxicidad in vitro contra osteosarcoma caninoes_ES
dc.typeTesis y disertaciones (Maestría y/o Doctorado)spa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audienceEspecializadaspa
Files
Original bundle
Now showing 1 - 2 of 2
thumbnail.default.alt
Name:
2018_DollyPatriciaPardo_Autorización.pdf
Size:
611.38 KB
Format:
Adobe Portable Document Format
Description:
Thumbnail Image
Name:
2018_DollyPatriciaPardoMora.pdf
Size:
2.23 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Doctorado en Ciencia aplicada