Evaluación de la expresión de subunidades recombinantes del receptor NMDA en la línea celular HEK-293.

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dc.contributor.advisorReyes Guzmán, Edwin Alfredospa
dc.contributor.advisorCuervo Soto, Laura Inésspa
dc.contributor.authorDuque Guevara, Stephany Valentinaspa
dc.creator.cedula11821727756spa
dc.date.accessioned2023-07-31T21:26:58Z
dc.date.available2023-07-31T21:26:58Z
dc.date.issued2023-05-29spa
dc.description.abstractThe NMDA (N-methyl-D-aspartate) receptor plays a crucial role in synaptic function and neuronal plasticity, but its hyperactivation can lead to excitotoxicity, a phenomenon implicated in several neurodegenerative diseases. In this context, the use of peptides derived from animal toxins has emerged as a promising strategy to selectively modulate NMDA receptor activity and counteract excitotoxicity. These peptides, from diverse sources such as snakes and spiders, act as specific ligands of the NMDA receptor and can function as agonists, antagonists or allosteric modulators, interacting with different binding sites on the receptor.eng
dc.description.abstractEl receptor NMDA (N-metil-D-aspartato) desempeña un papel crucial en la función sináptica y la plasticidad neuronal, pero su hiperactivación puede llevar a la excitotoxicidad, un fenómeno implicado en diversas enfermedades neurodegenerativas. En este contexto, el uso de péptidos derivados de toxinas animales ha surgido como una estrategia prometedora para modular selectivamente la actividad del receptor NMDA y contrarrestar la excitotoxicidad.spa
dc.description.degreelevelPregradospa
dc.description.degreenameBioquímico(a)spa
dc.description.degreetypeInvestigaciónspa
dc.description.notesPresencialspa
dc.identifier.bibliographicCitationAmico-Ruvio, S. A., Paganelli, M. A., Myers, J. M., & Popescu, G. K. (2012). Ifenprodil effects on GluN2B-containing glutamate receptors. Molecular Pharmacology, 82(6), 1074-1081. https://doi.org/10.1124/mol.112.078998.spa
dc.identifier.bibliographicCitationAsztély F, Gustafsson B. Ionotropic glutamate receptors: Their possible role in the expression of hippocampal synaptic plasticity. Mol Neurobiol. 1996;12(1):1–11.spa
dc.identifier.bibliographicCitationAizenman E, Frosch MP, Lipton SA. Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat. J Physiol. 1988;396(1):75–91.spa
dc.identifier.bibliographicCitationAndreou LV. Isolation of plasmid DNA from bacteria. Methods Enzymol. 2013;529:135-42. doi: 10.1016/B978-0-12-418687-3.00010-0. PMID: 24011041.spa
dc.identifier.bibliographicCitationAlbensi, B. C. (2007). The NMDA receptor/ion channel complex: a drug target for modulating synaptic plasticity and excitotoxicity. Current pharmaceutical design, 13(31), 3185-3194.spa
dc.identifier.bibliographicCitationAusubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., & Struhl, K. (Eds.). (2005). Current Protocols in Molecular Biology. John Wiley & Sons.spa
dc.identifier.bibliographicCitationBaez, S. D. L. C., García del Barco, D., Hardy-Sosa, A., Guillen Nieto, G., Bringas-Vega, M. L., Llibre-Guerra, J. J., & Valdes-Sosa, P. (2021). Scalable Bio marker combinations for early stroke diagnosis: A systematic review. Frontiers in neurology, 12, 638693.spa
dc.identifier.bibliographicCitationBeaudoin, G. M., Lee, S. H., Singh, D., Yuan, Y., Ng, Y. G., Reichardt, L. F., & Arikkath, J. (2012). Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex. Nature protocols, 7(9), 1741-1754.spa
dc.identifier.bibliographicCitationBeesley, S., Sullenberger, T., Pilli, J., Abbasi, S., Gunjan, A., & Kumar, S. S. (2019). Colocalization of distinct NMDA receptor subtypes at excitatory synapses in the entorhinal cortex. Journal of Neurophysiology, 121(1), 238-254. https://doi.org/10.1152/jn.00468.2018spa
dc.identifier.bibliographicCitationBermúdez Urrego, Y. S. (2022). Evaluation of the effect of the Pb53a a synthetic peptide obtained from toxins of the spider Phoneutria boliviensis on the cell viability of the HEK293 line.spa
dc.identifier.bibliographicCitationBermudez, S and Reyes-Guzman EA. (2020). Tesis de pregrado. Evaluation of the effect of the Pb53a, a synthetic peptide obtained from toxins of the spider Phoneutria boliviensis on the cell viability of the HEK-293 linespa
dc.identifier.instnameinstname:Universidad Antonio Nariñospa
dc.identifier.reponamereponame:Repositorio Institucional UANspa
dc.identifier.repourlrepourl:https://repositorio.uan.edu.co/spa
dc.identifier.urihttp://repositorio.uan.edu.co/handle/123456789/8345
dc.language.isospaspa
dc.publisherUniversidad Antonio Nariñospa
dc.publisher.campusBogotá - Circunvalarspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.programBioquímicaspa
dc.rightsAcceso abierto
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subjectBioquimicaes_ES
dc.subject.ddc574es_ES
dc.subject.ddc38.23 D946ees_ES
dc.subject.keywordBiochemistryes_ES
dc.titleEvaluación de la expresión de subunidades recombinantes del receptor NMDA en la línea celular HEK-293.es_ES
dc.typeTrabajo de grado (Pregrado y/o Especialización)spa
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1fspa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audienceGeneralspa
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