Rol de la Microglía en el desarrollo del Glioblastoma

Simple item page
dc.audienceEspecializada
dc.contributor.advisorLosada Barragán, Mónica
dc.contributor.authorGómez Rivas Gabriel Nicolas
dc.date.accessioned2024-11-13T16:42:31Z
dc.date.available2024-11-13T16:42:31Z
dc.date.created2024-06-26
dc.date.issued2024-11-13
dc.description.abstractGlioblastoma multiforme is one of the most aggressive brain cancers, with an average survival of less than 15 months. Its high proliferation, invasion and suppression capacity immune make it resistant to chemotherapy, radiotherapy and surgery. what drives development of new therapies. A key factor in its lethality is its tumor microenvironment, which is consisting mainly of the tumor and microglia. Microglia are exclusive macrophages of the central nervous system which serves as the main defender against an infection or signs of damage, through phagocytosis and pro-inflammatory or anti-inflammatory mechanisms depending on the severity and status of the infection or injury.
dc.description.degreelevelPregrado
dc.description.degreenameBiotecnólogo(a)
dc.description.degreetypeMonografía
dc.description.notesPresencial
dc.description.tableofcontentsEl glioblastoma multiforme es uno de los cánceres cerebrales más agresivos, con una media de supervivencia inferior a los 15 meses. Su alta proliferación, invasión y capacidad de supresión inmune lo hacen resistente a la quimioterapia, radioterapia y cirugía. lo que impulsa el desarrollo de nuevas terapias. Un factor clave en su letalidad es su microambiente tumoral, el cual, está constituido principalmente por el tumor y la microglía. La microglía es un macrófago exclusivo del sistema nervioso central el cual funge como principal defensor ante una infección o señales de daño, por medio fagocitosis y mecanismos proinflamatorios o antiinflamatorios dependiendo de la gravedad y estado de la infección o la lesión.
dc.description.versionfinal
dc.format.mediumpdf
dc.identifier.urihttps://repositorio.uan.edu.co/handle/123456789/11843
dc.language.isoEspañol
dc.publisherUniversidad Antonio Nariño
dc.publisher.campusBogotá - Circunvalar
dc.publisher.facultyFacultad de Ciencias
dc.publisher.programBiotecnología
dc.rights.accessrightsAcceso cerrado
dc.rights.coarhttp://purl.org/coar/access_right/c_16ec
dc.sourceinstname:Universidad Antonio Nariño
dc.source.bibliographicCitationAhir, B. K., Engelhard, H. H., & Lakka, S. S. (2020). Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma. In Molecular Neurobiology (Vol. 57, Issue 5, pp. 2461–2478). Springer. https://doi.org/10.1007/s12035-020-01892-8
dc.source.bibliographicCitationAlbakova, Z., Mangasarova, Y., Albakov, A., & Gorenkova, L. (2022). HSP70 and HSP90 in Cancer: Cytosolic, Endoplasmic Reticulum and Mitochondrial Chaperones of Tumorigenesis. In Frontiers in Oncology (Vol. 12). Frontiers Media S.A. https://doi.org/10.3389/fonc.2022.829520
dc.source.bibliographicCitationAllen, N. J., & Lyons, D. A. (n.d.). Glia as architects of central nervous system formation and function. http://science.sciencemag.org/
dc.source.bibliographicCitationAndersen, R. S., Anand, A., Harwood, D. S. L., & Kristensen, B. W. (2021). Tumorassociated microglia and macrophages in the glioblastoma microenvironment and their implications for therapy. In Cancers (Vol. 13, Issue 17). MDPI AG. https://doi.org/10.3390/cancers13174255
dc.source.bibliographicCitationBlitz, S. E., Kappel, A. D., Gessler, F. A., Klinger, N. V., Arnaout, O., Lu, Y., Peruzzi, P. P., Smith, T. R., Chiocca, E. A., Friedman, G. K., & Bernstock, J. D. (2022). TumorAssociated Macrophages/Microglia in Glioblastoma Oncolytic Virotherapy: A DoubleEdged Sword. In International Journal of Molecular Sciences (Vol. 23, Issue 3). MDPI. https://doi.org/10.3390/ijms23031808
dc.source.bibliographicCitationBuonfiglioli, A., & Hambardzumyan, D. (2021). Macrophages and microglia: the cerberus of glioblastoma. In Acta Neuropathologica Communications (Vol. 9, Issue 1). BioMed Central Ltd. https://doi.org/10.1186/s40478-021-01156-z
dc.source.bibliographicCitationCloughesy, T. F., Mochizuki, A. Y., Orpilla, J. R., Hugo, W., Lee, A. H., Davidson, T. B., Wang, A. C., Ellingson, B. M., Rytlewski, J. A., Sanders, C. M., Kawaguchi, E. S., Du, L., Li, G., Yong, W. H., Gaffey, S. C., Cohen, A. L., Mellinghoff, I. K., Lee, E. Q., Reardon, D. A., … Prins, R. M. (2019). Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma. Nature Medicine, 25(3), 477–486. https://doi.org/10.1038/s41591-018-0337-7
dc.source.bibliographicCitationCodrici, E., Popescu, I. D., Tanase, C., & Enciu, A. M. (2022). Friends with Benefits: Chemokines, Glioblastoma-Associated Microglia/Macrophages and Tumor Microenvironment. In International Journal of Molecular Sciences (Vol. 23, Issue 5). MDPI. https://doi.org/10.3390/ijms23052509
dc.source.bibliographicCitationDe Leo, A., Ugolini, A., & Veglia, F. (2021). Myeloid cells in glioblastoma microenvironment. In Cells (Vol. 10, Issue 1, pp. 1–20). MDPI. https://doi.org/10.3390/cells10010018
dc.source.bibliographicCitationDinarello, C. A. (2011). Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood, 117(14), 3720–3732. https://doi.org/10.1182/blood-2010-07-273417
dc.subjectMicroglia,
dc.subjectGlioblastoma
dc.subjectAngiogenesis
dc.subjectEvasión Immune
dc.subject.keywordMicroglia,
dc.subject.keywordGlioblastoma
dc.subject.keywordAngiogenesis
dc.subject.keywordImmune Evasion
dc.titleRol de la Microglía en el desarrollo del Glioblastoma
dc.typeTesis/Trabajo de grado - Monografía - Pregrado
dc.type.coarversionhttp://purl.org/coar/version/c_b1a7d7d4d402bcce
dc.type.documentEstudio descriptivo
dc.type.redcolhttp://purl.org/redcol/resource_type/PIC
dc.type.versionVersión original del autor, Borrador, Manuscrito
Files
Original bundle
Now showing 1 - 3 of 3
thumbnail.default.alt
Name:
2024_GabrielNicolasGomezRivas_Acta
Size:
1.54 MB
Format:
Adobe Portable Document Format
Description:
Acta
thumbnail.default.alt
Name:
2024_GabrielNicolasGomezRivas_Autorización
Size:
2.24 MB
Format:
Adobe Portable Document Format
Description:
Autorización
thumbnail.default.alt
Name:
2024_GabrielNicolasGomezRivas
Size:
740.22 KB
Format:
Adobe Portable Document Format
Description:
Trabajo de grado
Collections
Biotecnología