Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)Alfonso Rodríguez, Camilo AndresSánchez Hernández, VerónicaDiosa Cruz, KaterineRamirez Ballesteros, Ximena2021-03-032021-03-032020-11-27http://repositorio.uan.edu.co/handle/123456789/2621PropiaSince the beginning of tissue engineering in the early 1990s, numerous investigations have been developed focused on regenerative dentistry based on treating immature teeth with necrotic pulp, which consists of stimulating the tissues found in the root of the tooth, mainly by the synthesis of unique materials that act as scaffolds to support cell union, growth and differentiation, the above being possible, a sterile canal, must be accompanied by the combination of Hoshino's triple antibiotic paste. Studies have also been carried out with new bioceramics that help regeneration and have been the final step in pulpal revascularization. Objective: To evaluate the viability of apical papilla stem cells when exposed to the Triantibiotic paste of Hoshino and EcandoquenceDesde el inicio de la ingeniería de tejidos a principios de la década de 1990, se han desarrollado numerosas investigaciones enfocadas en la odontología regenerativa basados en tratar dientes inmaduros con pulpa necrótica, la cual consiste en la estimulación de los tejidos que se encuentran en la raíz del diente, principalmente por la síntesis de materiales únicos que actúan como andamios para apoyar la unión celular, el crecimiento y la diferenciación, siendo posible lo anterior, un conducto estéril, debe estar acompañado de la combinación de la pasta triple antibiótica de Hoshino. También se han realizado estudios con nuevos materiales biocerámicos que ayudan a la regeneración y han sido como paso final de la revascularización pulpar. 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