Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)Acosta Jurado, Diana CarolinaVelasco Lame Edduar2024-08-092024-08-092024-06-25https://repositorio.uan.edu.co/handle/123456789/9960Degenerative joint disease (DJD) in dogs, a concern both emotionally and clinically for owners and veterinarians, has sparked growing interest in exploring more effective therapeutic options. This study focused on investigating the therapeutic potential of cannabidiol (CBD) for pain management in dogs with DJD. Through a methodology that included the collection and classification of information from secondary sources, studies published between 2010 and 2022 addressing the pharmacokinetics and dynamics of CBD in this population were selected. The results revealed that CBD interacts with receptors of the endocannabinoid system (ECS), reducing the perception of pain and inflammation in joints affected by DJD. Additionally, it was observed that CBD preserves cartilage integrity and provides sustained pain relief, with therapeutic advantages over conventional analgesic therapy due to its safety profile and comprehensive ability to address underlying DJD symptoms.La enfermedad articular degenerativa (EAD) en caninos, una preocupación tanto emocional como clínica para dueños y veterinarios, ha generado un interés creciente en explorar opciones terapéuticas más efectivas. Este estudio se enfocó en investigar el potencial terapéutico del cannabidiol (CBD) para el manejo del dolor en caninos con EAD. A través de una metodología que incluyó la recopilación y clasificación de información de fuentes secundarias, se seleccionaron estudios publicados entre 2010 y 2022 que abordaran la farmacocinética y dinámica del CBD en esta población. Los resultados revelaron que el CBD interactúa con receptores del sistema endocannabinoide (SEC), reduciendo la percepción del dolor y la inflamación en las articulaciones afectadas por EAD. Además, se observó que el CBD preserva la integridad del cartílago y ofrece un alivio sostenido del dolor, con ventajas terapéuticas sobre la terapia analgésica convencional debido a su perfil de seguridad y capacidad integral para abordar los síntomas subyacentes de la EAD.PdfspaAcceso abiertodolorinflamaciónendocannabinoidescannabidiolpaininflammationendocannabinoidcannabinoidscannabidiol.Estudio descriptivoinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf21. Adams, R., & Moore, J. (2018). Pain and Behavior in Dogs with Osteoarthritis: A Longitudinal Study. Pain Management in Veterinary Practice, 45(7), 891-900.2. Adams, V. J., et al. (2016). Strategies for the Management and Prevention of Inherited Disorders in Dogs. The Veterinary Journal, 198, 47-56.3. Anderson, K. L., O’Neill, D. G., Brodbelt, D. C., Church, D. B., Meeson, R. L., Sargan, D., Summers, J. F., Zulch, H., & Collins, L. M. (2018). Prevalence, duration and risk factors for appendicular osteoarthritis in a UK dog population under primary veterinary care. Scientific Reports, 8(1), 1–12. https://doi.org/10.1038/s41598-018-23940-z4. Baker, S., & Green, D. (2022). Sleep Disturbances in Dogs with Osteoarthritis: A Comprehensive Analysis. Journal of Veterinary Sleep Research, 40(2), 201- 211.5. Bartner, R. McGrath, S. Rao, S. Hyatt, LK. Wittenburg, LA (2018) Pharmacokinetics of cannabidiol administered by 3 delivery methods at 2 different dosages to healthy dogs, Can. J. Vet. Res., 82(3), 178-183.6. Bermúdez, E. J., & Moreno, M. C. C. (2022). Generalidades sobre osteoartrosis (OA) canina. https://hdl.handle.net/20.500.12494/469307. Biosalud. (2019). Manejo del dolor crónico con extracto de Cannabis, en un grupo de pacientes de la ciudad de Manizales. Revista Ciencias Sociales, Biosalud. Recuperado de https://revistasojs.ucaldas.edu.co/index.php/biosalud/article/view/3656 478. Bischoff, K. (2018). Drugs of Use and Abuse. En: R. C. Gupta (Ed.), Veterinary Toxicology, Basic and Clinical Principles (Third, pp. 387-408). Academic Press.9. Bisogno T, Hanus L, De Petrocellis L, Tchilibon S, Ponde DE, Brandi I. (2001) Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol. 134(4):845–5210. Brown, A. (2019). The Social Consequences of Canine Osteoarthritis. Journal of Animal Behavior, 45(3), 201-210.