Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)Díaz Mora, Norma PatriciaRamírez Sulvarán, Jesús ArturoDávila Cuellar, Angélica MaríaGalavis Villamizar, Yulian Andrea2021-03-092021-03-092020-11-25http://repositorio.uan.edu.co/handle/123456789/2947PropiaObjective: The objective of this narrative review of the literature was to determine the healing and anti-inflammatory effect of Aloe vera and vitamin C on oral mucosa. Materials and methods: 126 articles related to the objective of the study were collected, these articles were read and analyzed and 50 of them were selected according to the inclusion and exclusion criteria, where the search parameter was the words: “Aloe” “inflammation” “mucosa” “cicatrization” “bacteria” “Ascorbic Acid” “wound healing” and Boolean operators such as “AND and “OR” were used applying the search to a period of the last 20 years. Results: When analyzing the results, it was determined that Aloe vera had a healing and anti-inflammatory effect in various lesions of the oral mucosa since it acts in the arachidonic acid pathway through cyclooxygenase, inhibiting inflammation, and it also did not present side effects in the clinical studies carried out. In patients, with respect to vitamin C it was determined that it has a healing and anti-inflammatory effect on oral mucosa since it regulates the inflammatory process and stimulates tissue repair, in addition, it modulates the release of catabolic inflammatory cytokines, promotes wound healing, Aloe vera had a high antibacterial effect against a variety of oral pathogens. Conclusion: Aloe vera and vitamin C are effective alternative treatments in terms of the healing and anti-inflammatory effect on oral mucosa lesions, however, regarding vitamin C there are no clinical studies regarding its direct topical application on oral mucosa and there is a controversy regarding its dosage. Aloe vera has an antibacterial effect against pathogens of the oral cavity, however, clinical studies are needed to determine what other pathogens Aloe vera can inhibit. Keywords: Aloe, ascorbic acid, mucosa, wound healing, inflammation, bacteria.Objetivo: el objetivo de esta revisión narrativa de la literatura fue determinar el efecto cicatrizante y antiinflamatorio del Aloe vera y la vitamina C en mucosa oral. Materiales y métodos: Se recopilaron 126 artículos relacionados con el objetivo del estudio, se realizó la lectura y el análisis de estos artículos y se seleccionaron 50 de estos según los criterios de inclusión y exclusión, donde se tuvo como parámetro de búsqueda las palabras: “Aloe” “inflammation” “mucosa” “cicatrización” “bacterias” Ascorbic Acid” “wound healing” y se utilizaron operadores booleanos como “AND y “OR” aplicando la búsqueda a un periodo de los últimos 20 años. Resultados: Al analizar los resultados se determinó que el Aloe vera presentó efecto cicatrizante y antiinflamatorio en diversas lesiones de la mucosa oral ya que actúa en la vía del ácido araquidónico a través de la ciclooxigenasa inhibiendo la inflamación, además no presentó efectos secundarios en los estudios clínicos realizados a pacientes, con respecto a la vitamina C se determinó tiene efecto cicatrizante y antiinflamatorio en mucosa oral ya que regula el proceso inflamatorio y estimula la reparación de los tejidos, además, modula la liberación de citocinas inflamatorias catabólicas, promueve la cicatrización de la herida, El Aloe vera presentó alto efecto antibacterial contra una variedad de patógenos orales. Conclusión: El Aloe vera y la vitamina C son tratamientos alternativos efectivos en cuanto al efecto cicatrizante y antiinflamatorio en lesiones de la mucosa oral, sin embargo, en cuanto a la vitamina C no hay estudios clínicos respecto a su aplicación tópica directa en mucosa oral y hay una controversia en cuanto a su dosificación. El Aloe vera tiene efecto antibacterial contra patógenos propios de la cavidad oral, sin embargo, hacen falta estudios clínicos para determinar que otros patógenos puede inhibir el Aloe vera. Palabras clave: Aloe, ácido ascórbico, mucosa bucal, cicatrización, inflamación, bacterias.spaAcceso abiertoAloeÁcido ascórbicoMucosa bucalCicatrizaciónInflamaciónBacteriasTrabajo de grado (Pregrado y/o Especialización)AloeAscorbic acidMucosaWound healingInflammationBacteriainfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Aghajanian, P., Hall, S., Wongworawat, M, D., & Mohan, S. 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