Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)Torres García, OrlandoSforcin, Jose MauricioGutiérrez, Rafael MaríaPardo Mora, Dolly Patricia2023-05-232023-05-232018-02-18http://repositorio.uan.edu.co/handle/123456789/8027Propolis is produced by honeybees from the resins and balsams of plants and characterized by its complex chemical composition. Bees use propolis to protect the hive, to seal holes and to avoid infectious diseases that may affect bee health. Humans have used propolis for medicinal purposes since ancient times, and its effectiveness as an antimicrobial, immunomodulatory, antiparasitic, and antitumor agent has been demonstrated recently.El propóleo es un material producido por las abejas a partir de resinas y bálsamos de plantas, caracterizado por su compleja composición química. Las abejas lo utilizan como medio de protección, sellando espacios y adicionalmente para evitar procesos infecciosos que puedan afectar la salud de la colmena. El humano ha usado el propóleo desde tiempos ancestrales con fines medicinales y en la época moderna ha sido posible demostrar su efecto como antimicrobiano, inmunomodulador, antiparasitario y antitumoral, entre otros.spaAcceso abiertoPropóleoOsteosarcomaApoptosisExpresión génica.14.18 P226pTesis y disertaciones (Maestría y/o Doctorado)PropolisOsteosarcomaApoptosisGene Expressioninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Ahn, M. R., Kunimasa, K., Ohta, T., Kumazawa, S., Kamihira, M., Kaji, K., . . . Nakayama, T. (2007). Suppression of tumor-induced angiogenesis by Brazilian propolis: Major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation. Cancer Letters, 252(2), 235-243. doi:10.1016/j.canlet.2006.12.039Al-Khan A., Gunn H.J., Day M.J., Tayebi M., Ryan S.D., Kuntz C.A., Saad E.S., Richardson S.J., Danks J.A. 2017. Immunohistochemical Validation of Spontaneously Arising Canine Osteosarcoma as a Model for Human Osteosarcoma. Journal of Comparative Pathology. Volume 157, Issue 4: 256-265Alday, E., Valencia, D., Carreno, A. L., Picerno, P., Piccinelli, A. L., Rastrelli, L., . . . Velazquez, C. (2015). Apoptotic induction by pinobanksin and some of its ester derivatives from Sonoran propolis in a B-cell lymphoma cell line. Chemico-Biological Interactions, 242, 35-44. doi:10.1016/j.cbi.2015.09.013Bankova, Castro, D., & Marcucci. (2000). Propolis: Recent advances in chemistry and plant origin. Apidologie, 31(1), 3-15.Bankova, V. (2005). Chemical diversity of propolis and the problem of standardization. Journal of Ethnopharmacology, 100(1–2), 114-117. doi:http://dx.doi.org/10.1016/j.jep.2005.05.004Bankova, V., Popova, M., & Trusheva, B. (2016). NEW EMERGING FIELDS OF APPLICATION OF PROPOLIS. Macedonian Journal of Chemistry and Chemical Engineering, 35(1), 1-11. doi:10.20450/mjcce.2016.864Bartolomeu, A. R., Frión-Herrera, Y., da Silva, L. M., Romagnoli, G. G., de Oliveira, D. E., & Sforcin, J. M. (2016). Combinatorial effects of geopropolis produced by Melipona fasciculata Smith with anticancer drugs against human laryngeal epidermoid carcinoma (HEp-2) cells. Biomedicine & Pharmacotherapy, 81, 48-55. doi:http://dx.doi.org/10.1016/j.biopha.2016.03.049Bernardino, P.N., Bersano, P.R.O., Lima Neto, J.F., Sforcin, J.M. Positive effects of antitumor drugs in combination with propolis on canine osteosarcoma cells (spOS- 2) and mesenchymal stem cells. Biomedicine & Pharmacotherapy, in press.Bertram, J. S. (2000). The molecular biology of cancer. Molecular Aspects of Medicine, 21(6), 167-223. doi:http://dx.doi.org/10.1016/S0098-2997(00)00007-8Bittencourt, M. L. F., Ribeiro, P. R., Franco, R. L. P., Hilhorst, H. W. M., de Castro, R. D., & Fernandez, L. G. (2015). Metabolite profiling, antioxidant and antibacterial activities of Brazilian propolis: Use of correlation and multivariate analyses to identify potential bioactive compounds. Food Research International, 76, 449-457. doi:10.1016/j.foodres.2015.07.008instname:Universidad Antonio Nariñoreponame:Repositorio Institucional UANrepourl:https://repositorio.uan.edu.co/