Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)Losada Barragán, MónicaVargas Sánchez, Jeinny KarinaVargas Romero, Laura Alejandra2023-07-102023-07-102023-06-01http://repositorio.uan.edu.co/handle/123456789/8177Glioblastoma is an aggressive and difficult to treat type of brain tumor. However, it has been proposed that ketogenic therapy could have beneficial effects in controlling its tumor activity. This diet, rich in fatty acids, acts as natural ligands for PPAR receptors, which regulate inflammatory, metabolic and cell growth processes.El glioblastoma es un tipo de tumor cerebral agresivo y difícil de tratar. Sin embargo, se ha propuesto que la terapia cetogénica podría tener efectos beneficiosos en el control de su actividad tumoral. Esta dieta, rica en ácidos grasos, actúa como ligandos naturales de los receptores PPAR, que regulan procesos inflamatorios, metabólicos y de crecimiento celular.spaAcceso abiertoglioblastomadieta cetogénicaexpresión génicacrecimiento tumoralácidos octanoicoácido decanoico574166.23 V297eTesis y disertaciones (Maestría y/o Doctorado)glioblastomaketogenic dietgene expressiontumor growthoctanoic aciddecanoic acidinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Tan, A.C., Ashley, D. M., López, G. Y., Malinzak, M., Friedman, H. S., & Khasraw, M. , Management of glioblastoma: State of the art and future directions. CA: a cancer journal for clinicians, 2020. 70(4): p. 299-312.Stadlbauer, A., Marhold, F., Oberndorfer, S., Heinz, G., Zimmermann, M., Buchfelder, M., ... & Kinfe, T. M., Metabolic Tumor Microenvironment Characterization of Contrast Enhancing Brain Tumors Using Physiologic MRI. Metabolites, 2021. 11(10): p. 668.Wesolowska, A., Kwiatkowska, A., Slomnicki, L., Dembinski, M., Master, A.,Sliwa, M., ... & Kaminska, B. , Microglia-derived TGF-β as an important regulator of glioblastoma invasion—an inhibition of TGF-β-dependent effects by shRNA against human TGF-β type II receptor. Oncogene, 2008. 27(7): p. 918-930.Sowers, J., Johnson, KM, Conrad, C., Patterson, JT y Sowers, LC, The role of inflammation in brain cancer. . Inflammation and Cancer, 2014: p. 75-105.Komohara, Y., Ohnishi, K., Kuratsu, J., & Takeya, M. , Possible involvement of the M2 anti‐inflammatory macrophage phenotype in growth of human gliomas. . The Journal of Pathology: A Journal of the Pathological Society of Great Britain and Ireland, 2008. 216(1): p. 15-24.Conroy, S., Kruyt, F. A., Wagemakers, M., Bhat, K. P., & den Dunnen, W. F., IL8 associates with a pro-angiogenic and mesenchymal subtype in glioblastoma. Oncotarget, 2018. 9(21): p. 15721.Mendes, O., Kim, H. T., & Stoica, G. , Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model. . Clinical & experimental metastasis, 2005. 22(3): p. 237-246.Lefranc, F., Sadeghi, N., Camby, I., Metens, T., Dewitte, O., & Kiss, R. , Present and potential future issues in glioblastoma treatment. . Expert review of anticancer therapy, 2006. 6(5): p. 719-732.Ramírez Camacho, A., Meavilla, S., Catalán, N., Gutiérrez, A., & Campistol Plana, J., Experiencia con la dieta cetogénica como tratamiento en la epilepsia refractaria. Revista de Neurologia, 2011. 53(9): p. 524-530.Zhou, W., Mukherjee, P., Kiebish, M. A., Markis, W. T., Mantis, J. G., & Seyfried, T. N., The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer. Nutrition & metabolism. , 2007. 41: p. 1-15instname:Universidad Antonio Nariñoreponame:Repositorio Institucional UANrepourl:https://repositorio.uan.edu.co/