Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)Reyes Guzmán, Edwin AlfredoCuervo Soto, Laura InésDuque Guevara, Stephany Valentina2023-07-312023-07-312023-05-29http://repositorio.uan.edu.co/handle/123456789/8345The NMDA (N-methyl-D-aspartate) receptor plays a crucial role in synaptic function and neuronal plasticity, but its hyperactivation can lead to excitotoxicity, a phenomenon implicated in several neurodegenerative diseases. In this context, the use of peptides derived from animal toxins has emerged as a promising strategy to selectively modulate NMDA receptor activity and counteract excitotoxicity. These peptides, from diverse sources such as snakes and spiders, act as specific ligands of the NMDA receptor and can function as agonists, antagonists or allosteric modulators, interacting with different binding sites on the receptor.El receptor NMDA (N-metil-D-aspartato) desempeña un papel crucial en la función sináptica y la plasticidad neuronal, pero su hiperactivación puede llevar a la excitotoxicidad, un fenómeno implicado en diversas enfermedades neurodegenerativas. En este contexto, el uso de péptidos derivados de toxinas animales ha surgido como una estrategia prometedora para modular selectivamente la actividad del receptor NMDA y contrarrestar la excitotoxicidad.spaAcceso abiertoBioquimica57438.23 D946eTrabajo de grado (Pregrado y/o Especialización)Biochemistryinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Amico-Ruvio, S. A., Paganelli, M. A., Myers, J. M., & Popescu, G. K. (2012). Ifenprodil effects on GluN2B-containing glutamate receptors. Molecular Pharmacology, 82(6), 1074-1081. https://doi.org/10.1124/mol.112.078998.Asztély F, Gustafsson B. Ionotropic glutamate receptors: Their possible role in the expression of hippocampal synaptic plasticity. Mol Neurobiol. 1996;12(1):1–11.Aizenman E, Frosch MP, Lipton SA. Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat. J Physiol. 1988;396(1):75–91.Andreou LV. Isolation of plasmid DNA from bacteria. Methods Enzymol. 2013;529:135-42. doi: 10.1016/B978-0-12-418687-3.00010-0. PMID: 24011041.Albensi, B. C. (2007). The NMDA receptor/ion channel complex: a drug target for modulating synaptic plasticity and excitotoxicity. Current pharmaceutical design, 13(31), 3185-3194.Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., & Struhl, K. (Eds.). (2005). Current Protocols in Molecular Biology. John Wiley & Sons.Baez, S. D. L. C., García del Barco, D., Hardy-Sosa, A., Guillen Nieto, G., Bringas-Vega, M. L., Llibre-Guerra, J. J., & Valdes-Sosa, P. (2021). Scalable Bio marker combinations for early stroke diagnosis: A systematic review. Frontiers in neurology, 12, 638693.Beaudoin, G. M., Lee, S. H., Singh, D., Yuan, Y., Ng, Y. G., Reichardt, L. F., & Arikkath, J. (2012). Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex. Nature protocols, 7(9), 1741-1754.Beesley, S., Sullenberger, T., Pilli, J., Abbasi, S., Gunjan, A., & Kumar, S. S. (2019). Colocalization of distinct NMDA receptor subtypes at excitatory synapses in the entorhinal cortex. Journal of Neurophysiology, 121(1), 238-254. https://doi.org/10.1152/jn.00468.2018Bermúdez Urrego, Y. S. (2022). Evaluation of the effect of the Pb53a a synthetic peptide obtained from toxins of the spider Phoneutria boliviensis on the cell viability of the HEK293 line.Bermudez, S and Reyes-Guzman EA. (2020). Tesis de pregrado. Evaluation of the effect of the Pb53a, a synthetic peptide obtained from toxins of the spider Phoneutria boliviensis on the cell viability of the HEK-293 lineinstname:Universidad Antonio Nariñoreponame:Repositorio Institucional UANrepourl:https://repositorio.uan.edu.co/