Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)Vargas Vargas, Rafael AntonioForero Garzón, Diego AlexanderFranco Restrepo, Juan Esteban2021-10-262021-10-262021-06-28http://repositorio.uan.edu.co/handle/123456789/5090Stress is a risk factor for several organic diseases including psychiatric disorders such as anxiety, depression, and substances use disorders, among others. Alcohol is a widely used substance in the world and its acute effects on a behavioral level are known. The effect of environmental stress and substances on behavior has been studied separately. Short and long-term stress in zebrafish can generate alterations in the CNS affecting anxiety levels in different behavioral tests such as locomotion, social, learning and memory behavior. However, in the brain, the molecular effects of environmental stress are poorly understood in association with alcohol and other substances such as caffeine, consumed throughout the world.El estrés es un factor de riesgo para diversas enfermedades orgánicas incluyendo trastornos psiquiátricos como la ansiedad, depresión, consumo de sustancias adictivas entre otros. El alcohol es una sustancia ampliamente usada en el mundo y sus efectos agudos a nivel comportamental son conocidos. El efecto del estrés ambiental y sustancias sobre el comportamiento se ha estudiado por separado. El estrés a corto y largo plazo en el pez cebra puede generar alteraciones en el SNC afectando los niveles de ansiedad en diferentes pruebas del comportamiento tales como la conducta motora, social, aprendizaje y memoria. Sin embargo, a nivel molecular en el cerebro son poco conocidos los efectos del estrés ambiental en conjunto con el alcohol y otras sustancias como la cafeína, consumidas en todo el mundo.spaAcceso abiertoPez CebraCafeinaEtanolEstrésTesis y disertaciones (Maestría y/o Doctorado)Zebra fishCaffeinEthanolStressinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Abreu, M., Koakoski, G., Ferreira, D., Oliveira, T., Rosa, J., & Gusso, D. et al. (2014). Diazepam and Fluoxetine Decrease the Stress Response in Zebrafish. Plos ONE, 9(7), e103232. doi: 10.1371/journal.pone.0103232Alazizi, A., Liu, M., Williams, F., Kurogi, K., Sakakibara, Y., Suiko, M., & Liu, M. (2011). Identification, characterization, and ontogenic study of a catechol O-methyltransferase from zebrafish. Aquatic Toxicology, 102(1-2), 18-23. doi: 10.1016/j.aquatox.2010.12.016Asakawa, K., Suster, M. L., Mizusawa, K., Nagayoshi, S., Kotani, T., Urasaki, A.,Kishimoto, Y., Hibi, M. and Kawakami, K. (2008). Genetic dissection of neuralcircuits by Tol2 transposon-mediated Gal4 gene and enhancer trapping in zebrafish.Proc. Natl. Acad. Sci. USA 105, 1255-1260.Barreto-Valer, K., López-Bellido, R., Macho Sánchez-Simón, F., & Rodríguez, R. (2012). Modulation by Cocaine of Dopamine Receptors through miRNA-133b in Zebrafish Embryos. Plos ONE, 7(12), e52701. doi: 10.1371/journal.pone.0052701Cachat J, Canavello P, Elegante M, Bartels B, Hart P, Bergner C, et al. Modeling withdrawal syndrome in zebrafish. Behav Brain Res. 208.2 (2010), pp. 371-376. https://doi.org/10.1016/j.bbr.2009.12.004Castaño, G., Sierra, G., Sánchez, D., Torres, Y., Salas, C., & Buitrago, C. (2017). Trastornos mentales y consumo de drogas en la población víctima del conflicto armado en tres ciudades de Colombia. Biomédica, 38, 77–92.doi:10.7705/biomedica.v38i0.3890Daré, L., Bruand, P., Gérard, D., Marin, B., Lameyre, V., Boumédiène, F., & Preux, P. (2019). Co-morbidities of mental disorders and chronic physical diseases in developing and emerging countries: a meta-analysis. BMC Public Health, 19(1). doi: 10.1186/s12889-019-6623-6Echevarria DJ, Hammack CM, Jouandot DJ, Toms CN. Does Acute Alcohol Exposure Modulate Aggressive Behaviors in the Zebrafish (Danio rerio), or is the Bark Worse than the Bite? Int J Comp Psychol. 23 (2010). https://escholarship.org/uc/item/2px3t3jcEddins, D., Petro, A., Williams, P., Cerutti, D., & Levin, E. (2008). Nicotine effects on learning in zebrafish: the role of dopaminergic systems. Psychopharmacology, 202(1-3), 103-109. doi: 10.1007/s00213-008-1287-4Emerson, A. J., Kappenman, D. P., Ronan, P. J., Renner, K. J., and Summers, C. H. (2000). Stress induces rapid changes in serotonergic activity: restraint and exertion. Behav. Brain Res. 111, 83–92. doi: 10.1016/s0166- 4328(00) 00143-1instname:Universidad Antonio Nariñoreponame:Repositorio Institucional UANrepourl:https://repositorio.uan.edu.co/